The tournament hosts secured top spot in Group A on Friday, thrashing Bolivia 5-0 to make sure they would remain in the capital city for the next round.
Uruguay, meanwhile, qualified for the last eight after finishing as one of the best third-placed teams. In a repeat of the 2011 final, the reigning champions drew their final Group B match 1-1 with Paraguay on Saturday, who will play in the fourth quarter-final in Concepcion on June 27.
Having beaten Jamaica 1-0 in Vina del Mar on Saturday, Group B winners Argentina will be back at the same venue for their next outing. They will play the third-placed finisher from either Group A or C.
Bolivia are also through to the knockout stages after finishing behind Chile in Group A – they will take on the second-placed team from Group C, in Temuco on June 25.