CR7 scored in the opening 10 minutes with an assist from Isco against Celta Vigo, going past England international Jimmy Greaves.
Ronaldo curled in a left-footed shot to reach the incredible goal scoring mark as he now has 367 goals in Europe’s top leagues.
Earlier Cristiano reached his 400th goal for Real Madrid when he found the net in the Los Blancos win over Sevilla.
Ronaldo scored twice against Sevilla, as he equaled Greaves record as all-time list of league goals.
Ron now has scored 283 goals in the league for Real, while having scored 84 goals in the Premier League with Manchester United.
He then added his second goal just three minutes into the second half to take his tally to 368 league goals with another assist from Isco.
Second in the list is his fierce rival and Barcelona superstar Lionel Messi, who is also lurking at the record with 346 league goals – since making his debut back in 2004.
Next in line of active players is Manchester United superstar Zlatan Ibrahimovic – who has 268 league goals to his name.
However, Ibra is the only player in the top 20 to have scored in three or more leagues with his stints at Barcelona, AC Milan, Inter Milan, Juventus, Paris Saint Germain, Ajax and now Manchester United.